Skin Science

 Skin Genetics

 

Sample DNA Report

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Scientific Advisory Board

Robert Ricciardi
Ph.D. Chief Scientific Officer

Dr. Robert Ricciardi is a Professor of Microbiology at the University of Pennsylvania, where he is a Graduate Group Chairman. He received his Ph.D. from the University of Illinois and was a Fellow at Harvard Medical School. He developed one of the first genomic technologies, widely used to identify hundreds of genes. He discovered one of the first activators that can also make cells cancerous by escaping the immune system. He is applying his new method (U.S. Patent) for screening tens of thousands of compounds to find therapeutics to prevent viral diseases. Dr. Ricciardi has authored 93 publications, served as a consultant to Children’s Hospital of Philadelphia, Smith Kline Pharmaceuticals, the NIH, and was awarded a NATO visiting Professorship.



Bernard L. Kasten
M.D. Chairman

Dr. Kasten is the Executive Chairman of the Board of GeneLink Inc. Companies and serves as Chief Medical Officer of GeneWize Life Sciences. Dr. Kasten has been a scientific advisor to the Company since 1999 and a member of the Company’s Advisory Committee since 2001. He is a graduate of Miami University (Oxford, Ohio), BA Chemistry, and the Ohio State University College of Medicine, MD. Dr. Kasten is a Diplomat of the American Board of Pathology with Certification in Anatomic and Clinical Pathology, with sub-specialty certification in Medical Microbiology. Dr. Kasten is an author of “Infectious Disease Handbook,” 1st through 5th Editions and the “Laboratory Test Handbook,” 1st through 4th Editions.



Harold H. Harrison
M.D., Ph.D., F.C.A.P

Dr. Harrison has served as Corporate Medical Director of Genetic Services for Quest Diagnostics, and as overall Medical Director for the biochemical, molecular, cytogenetic, and HLA laboratories of Genetrix, Inc., a national genetic services company that was acquired by GenzymeGenetics in 1997. Dr. Harrison is a Fellow of the College of American Pathologists and a member of the American College of Medical Genetics and American Society of Human Genetics. He holds medical licenses in six states (AZ, CA, IL, NJ, NV and NY), and laboratory director’s licensure in NJ and NY. Dr. Harrison currently holds a clinical faculty appointment with the University of Arizona Medical School.



Donald J. Cannon
Ph.D.

Dr. Cannon received his A.B. in Chemistry from Harvard College and an M.A. in Medical Sciences and a Ph.D. in Biochemistry from Boston University. He has been on the faculty at the Medical Schools at the University of Hawaii, University of Arkansas, and Marshall University where he was director of the Pathology residency program. He has performed research at the Boston Biomedical Research Institute, the Little Rock, Arkansas VAMC and the Bethesda Hospitals in Cincinnati. He has over 130 publications, and is a member of the American Association for Clinical Chemistry, the Association of Clinical Scientists and the National Academy of Clinical Biochemistry. Dr. Cannon is currently Professor of Chemistry and Director of the Forensic Sciences program at the University of Tampa.



James W. Simpkins
Ph.D. 

Dr. James W. Simpkins received his B.S. and M.S. degrees from the University of Toledo and received a Ph.D. in Physiology from Michigan State University. He has served as Chairman of the Department of Pharmacodynamics, Chairman of the Department of Pharmaceutics, Associate Dean for Research and Graduate Studies and Director for the Center for the Neurobiology of Aging at the University of Florida. He has more than 295 peer-reviewed publications, a dozen patents for his discoveries and has edited two texts on Alzheimer’s therapy. In July of 2000, he became the Chair of the Department of Pharmacology and Neuroscience, and is the Director at the Institute for Aging and Alzheimer’s disease research at the University of North Texas Health Science at Fort Worth.



Robert Kagan
M.D., F.C.A.P. 

Dr. Kagan is Board Certified in Clinical Pathology, Nuclear Medicine and Hyperbaric Medicine. He received his medical degree from Georgetown University School of Medicine. His postgraduate medical education included a medical internship at the University of California San Francisco and residency training programs in Pathology and Nuclear Medicine at the National Institute of Health. Dr. Kagan is again on the cutting edge of science as the Medical Director of BodyView, the first full body scanning facility to offer a programmatic approach to healthcare. Prior to opening the first outpatient MRI center in Florida, Dr. Kagan was the Medical Director of Nuclear Medicine at Holy Cross Hospital in Fort Lauderdale and Clinical Assistant Professor of Radiology at the University of Miami.

 

The Basics of SNP (Genetic) Technology

The awesome feat of compiling the Book of Life was accomplished by technologies that spelled out the entire human DNA genome. Get the full story by clicking here : Genetic Compass

CHAPTERS

FORWARD: HOW GENOMIC SCIENCES HAVE USHERED IN
THE NEW ERA OF PERSONALIZED NUTRITION & SKIN CARE
GENOMICS AS A TOOL FOR WELLNESS
GENOMICS – THE HUMAN BOOK OF LIFE
THE NEW SCIENCES OF NUTRAGENETICS & DERMAGENETICS
APPLICATIONS OF SNP TESTING: OXIDATION – THE PARADOX OF LIFE
PROBABILITY OF RESISTANCE TO OXIDATIVE STRESS
CUSTOMIZING PERSONAL CARE FORMULATIONS BASED ON NEEDS
INFORMATION ON PATIENT RESULTS
THE FUTURE.
FREQUENTLY ASKED QUESTIONS
REFERENCES
GLOSSARY
CONTRIBUTORS

 

DNA Customized Nutrition In a Nutshell

Everybody has unique DNA. This means we have somewhat different biochemistries and therefore different nutritional needs, especially for disadvantaged DNA.

DNA-customized nutrition is based on SNPs (single nucleotide polymorphisms.)

Your DNA includes the master code for proteins including enzymes. Common variations in a single nucleotide means that you are unable to properly code for a protein or enzyme. This happens surprisingly frequently but most of the time that doesn’t make much detectable difference for health, or the risk factors from this are low. Occasionally the SNP is profoundly important to our health, occurs frequently in people and is actionable with nutrition. Those are the ones we work with. Many of these SNPs are related to the healthy aging of our arteries, brain, lungs, joints, skin and more.

For example, if you have a disadvantaged epoxide SNP this means that you may not be able to form a sufficient amount of the enzyme critical to detoxifying chemicals in gasoline fumes, charcoal grilling, cigarette or wood burning smoke etc. Your DNA test detects that you have a negative variation (or glitch—i.e. cannot code properly for this enzyme) in your DNA and gives you nutrients to enable your body to amplify that protective enzyme, despite your DNA. In this case it is a green tea extract which evidence shows increases the gene expression or activity of microsomal epoxide hydrolase.

If like most people you have no idea that you have this disadvantaged SNP and do nothing, the risk factors can be premature aging, poor immunity, cardiovascular issues, fatigue and loss of appetite.

The SNPs deal with major areas of health: oxidative stress, environmental challenges, cardiovascular health, detoxification, immune health, neurological health, pulmonary health, eye/vision health and bone health

There are often 60- 80 ingredients in a formula—the odds are low of just eating well and randomly hitting the specific nutrients which are optimal for a person’s unique needs. There are over half a million possible combinations of mostly food-sourced nutrients to compensate for the disadvantaged biochemistry caused by the SNP. Thus, each DNA customized formula which matches a person’s DNA to their nutrition is one out of half a million—giving them optimal nutritional support for their unique genetics and DNA driven biochemistry.

Why We Look at Specific SNPs

Although human DNA contains several million natural genetic variations (called SNPs scientists used the following criteria to choose the SNPs for the Healthy Aging DNA Assessment:

1. Valid: The existence of the SNP is supported by solid, credible, scientific evidence.

2. Important: A SNP predicts biochemical processes that are associated with significant physiological disadvantages. In short the SNP can profoundly impact your health

3. Frequent: the SNP is relatively common among the general population. In short, most people have many of these SNPs which can interfere with healthy aging.

4. Actionable: A SNP’s negative potential has been scientifically proven to be modulated by nutritional supplementation. In short, we can do something about the SNP with supplemental nutrients.

We assess twelve healthy aging genes to tell you what aging problems you’re likely to face.

The information can then used to customize a nutritional supplement using a blend of phytonutrients and antioxidants selected to compensate for particular deficiencies in areas of bone and heart health, oxidative stress, lung and breast tissue health, immune health, eye health, joint health, skin health, brain and cognitive health and your ability to detoxify pollutants.

These are the SNPs we look at and why

SNP’s Assessed:

  • VDR Gene (Vitamin D Receptor) : Helps understand the Vitamin D receptor’s  ability to use vitamin D.
  • EPHX Gene (Microsomal Epoxide Hyrodase) : Helps understand the individual’s ability to  detoxify from  pollutants, pesticides, alcohol, tobacco, and other foreign chemicals.
  • NQOI (Coenzyme Q10 Reductase) : Determines which form of CoQ10 (ubiquinone, ubiquinol) is needed  to help fight free radicals.
  • SOD2 (Manganese Superoxide Dismutase) : Ability to protect against oxidative stress by eliminating toxic superoxide free radicals.
  • GPX1 (Glutathione Peroxidase 1) : Ability to protect against oxidative stress by eliminating hydrogen peroxide and hydroxyl radicals.
  • MMP-1 (Matrix Metalloproteinase) : Capable of degrading collagen, which is the main component in cartilage, ligaments, and bone.
  • MTRR (Methionine Synthase Reductase) : Ability to keep homocysteine in check to preserve cardiovascular health.
  • MTHFR Gene (Methylene Tetrahydrofolate Reductase) : Determines which form of folic acid (folate or L-methyfolate) your body needs to help clear homocysteine.
  • TNF-ALPHA (Tumor Necrosis Factor) : Ability to regulate the inflammatory response.
  • PON-1 (Paraoxonase 1) : Ability to protect LDL from oxidation.
  • CYP11B2 (Aldosterone Synthase) : Ability to maintain blood pressure in normal ranges, essential for a healthy heart.
  • ApoB (Apolipoprotein B) : Ability to support a healthy heart and maintain healthy blood lipids
Cardiovascular Gene     MTRR The CoQ10 Gene NQ01
Cardiovascular Enzyme Gene MTHFR The SuperOxide Gene SOD2
Cholesterol Oxidation Gene PON-1 The Vitamin D Gene     VDR
Cholesterol Gene ApoB Antioxidative Gene GPX1
Blood Pressure Gene CYP11B2 The Detox Gene EPHX
Inflammation Response Gene TNF-ALPHA Collagen Health Gene MMP-1

 

Let’s Go Over Each One Separately

Vitamin D Receptor SNP (VDR)

Science is finding that Vitamin D is an amazing nutrient that affects so many health issues. The effective absorption of serum vitamin D can be disadvantaged by a SNP in this gene. Bone density in particular and potentially sugar regulation, parathyroid hormone, and normal cell division, can be affected.

Detoxification SNP (EPHX)

In today’s world we are bombarded by toxins and pollutants that can cause many health issues and premature aging. Detoxification from pollutants and toxins can be disadvantaged by a SNP which lowers activity of a critical enzyme, epoxide hydrolase. Supportive nutrition increases the activity of that enzyme, and supports natural mechanisms the liver uses to detoxify.

Co-Q10 SNP (NQ01)

Co-Q10 is so important to brain and heart health. Presence of a key healthy aging anti-oxidant, co-enzymeQ10, can be disadvantaged in the ability to reduce the precursor form of Co-Q10 to its usable form, everybody is provided Co-Q10 but if the SNP is detected the correct form of Co-Q10 s provided.

Free Radical Defense SNP ( SOD2)

Science is showing that free radicals are a major culprit in aging and health issues. The ability to defend against one of the most damaging free radicals toxic to DNA, cell machinery and tissues can be disadvantaged by this SNP which lowers the activity of a key protective enzyme. This can interfere with healthy aging. Supportive nutrition increases this enzyme and includes anti-oxidants with specific activity against this free radical. 

Free Radical Defense SNP (GPX1)

This free radical can damage eye tissue, breast, and prostate tissue and affect heart health. The ability to synthesize and repair DNA, metabolism of toxins, and immune enhancement can be disadvantaged by this SNP which lowers the activity of a key enzyme. This can interfere with healthy aging. Supportive nutrients increase the enzyme, and include anti-oxidants and selenium to further protect against this free radical.

Collagen Health SNP (MMP-1)

Collagen is the main protein in your body and critical to bone and joint health. It also provides structural stability to blood vessels. A healthy collagen balance in the joints, cartilage and skin can be disadvantaged by this SNP. This can especially affect joint health and skin aging. Supportive nutrition strengthens collagen and protects it from free radical damage.

Cardiovascular SNP (MTRR- Homocystein)

This Gene SNP can profoundly affect cardiovascular health and healthy aging. The ability to clear the blood of a damaging amino acid, homcystein, can be disadvantaged by this SNP. High levels of homocystein can profoundly affect cardiovascular health. Supportive nutrients lower homocystein levels and support over-all cardiovascular health.

Cardiovascular Enzyme SNP (MTHFR)

This determines what form of folate works for your body and is an important factor in your heart health. The ability to regulate healthy levels of homocystein can be disadvantaged by this SNP. Supportive nutrients, including the circulating form of folate, help reduce homocystein. 

Immune Balance SNP (TNF-ALPHA)

Science is showing that inflammation underlies many of our most serious health and cardiovascular issues. A balanced immune system, one that does not produce excessive and uncontrolled inflammation, can be disadvantaged by this SNP. Supportive nutrients provide anti-oxidants that regulate TNF levels to balance immunity. 

Cholesterol Oxidation SNP (PON-1)

This Gene SNP is so important for keeping our arteries healthy. This plays a major role in cardiovascular issues that profoundly affect our health and ability to age well. Healthy levels of an enzyme that protects LDL from oxidizing can be disadvantaged with this SNP. Oxidized cholesterol plays a major role in cardiovascular health. Supportive ingredients help protect LDL from oxidizing and increase the activity of the protective enzyme.

Artery Regulation SNP (CYP11B2)

A healthy cardiovascular system needs to stay flexible and adjust readily to different demands on the heart. The regulation of blood pressure and of the ability of arteries to relax and constrict can be disadvantaged by this SNP. Both of these can impact cardiovascular health. Supportive nutrients help maintain blood pressure levels and strengthen the heart.

Cholesterol SNP (ApoB)

Cholesterol plays a role in a healthy cardiovascular system. Healthy levels of LDL, cholesterol, triglycerides, healthy circulation to the heart and brain, and glucose tolerance can be disadvantaged by this SNP. Supportive nutrients reduce ApoB production, prevent LDL oxidation and reduce bad cholesterol.